Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae.
Identifieur interne : 001073 ( Main/Exploration ); précédent : 001072; suivant : 001074Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae.
Auteurs : C M Grant [Australie] ; S. Luikenhuis ; A. Beckhouse ; M. Soderbergh ; I W DawesSource :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2000.
Descripteurs français
- KwdFr :
- Biosynthèse des protéines (MeSH), Facteurs de transcription (métabolisme), Glutarédoxines (MeSH), Isoformes de protéines (biosynthèse), Isoformes de protéines (génétique), Oxidoreductases (MeSH), Protéines (génétique), Protéines de Saccharomyces cerevisiae (MeSH), Protéines de liaison à l'ADN (métabolisme), Protéines fongiques (génétique), Régulation de l'expression des gènes (MeSH), Saccharomyces cerevisiae (croissance et développement), Saccharomyces cerevisiae (génétique), Stress oxydatif (MeSH).
- MESH :
- biosynthèse : Isoformes de protéines.
- croissance et développement : Saccharomyces cerevisiae.
- génétique : Isoformes de protéines, Protéines, Protéines fongiques, Saccharomyces cerevisiae.
- métabolisme : Facteurs de transcription, Protéines de liaison à l'ADN.
- Biosynthèse des protéines, Glutarédoxines, Oxidoreductases, Protéines de Saccharomyces cerevisiae, Régulation de l'expression des gènes, Stress oxydatif.
English descriptors
- KwdEn :
- DNA-Binding Proteins (metabolism), Fungal Proteins (genetics), Gene Expression Regulation (MeSH), Glutaredoxins (MeSH), Oxidative Stress (MeSH), Oxidoreductases (MeSH), Protein Biosynthesis (MeSH), Protein Isoforms (biosynthesis), Protein Isoforms (genetics), Proteins (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae Proteins (MeSH), Transcription Factors (metabolism).
- MESH :
- chemical , biosynthesis : Protein Isoforms.
- chemical , genetics : Fungal Proteins, Protein Isoforms, Proteins.
- chemical , metabolism : DNA-Binding Proteins, Transcription Factors.
- genetics : Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- Gene Expression Regulation, Glutaredoxins, Oxidative Stress, Oxidoreductases, Protein Biosynthesis, Saccharomyces cerevisiae Proteins.
Abstract
Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We report here that the expression of both genes is induced in response to various stress conditions including oxidative, osmotic, and heat stress and in response to stationary phase growth and growth on non-fermentable carbon sources. Furthermore, both genes are activated by the high-osmolarity glycerol pathway and negatively regulated by the Ras-protein kinase A pathway via stress-responsive STRE elements. GRX1 contains a single STRE element and is induced to significantly higher levels compared to GRX2 following heat and osmotic shock. GRX2 contains two STRE elements, and is rapidly induced in response to reactive oxygen species and upon entry into stationary phase growth. Thus, these data support the idea that the two glutaredoxin isoforms in yeast play distinct roles during normal cellular growth and in response to stress conditions.
DOI: 10.1016/s0167-4781(99)00234-1
PubMed: 10786615
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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We report here that the expression of both genes is induced in response to various stress conditions including oxidative, osmotic, and heat stress and in response to stationary phase growth and growth on non-fermentable carbon sources. Furthermore, both genes are activated by the high-osmolarity glycerol pathway and negatively regulated by the Ras-protein kinase A pathway via stress-responsive STRE elements. GRX1 contains a single STRE element and is induced to significantly higher levels compared to GRX2 following heat and osmotic shock. GRX2 contains two STRE elements, and is rapidly induced in response to reactive oxygen species and upon entry into stationary phase growth. Thus, these data support the idea that the two glutaredoxin isoforms in yeast play distinct roles during normal cellular growth and in response to stress conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10786615</PMID><DateCompleted><Year>2000</Year><Month>05</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-3002</ISSN><JournalIssue CitedMedium="Print"><Volume>1490</Volume><Issue>1-2</Issue><PubDate><Year>2000</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Biochimica et biophysica acta</Title><ISOAbbreviation>Biochim Biophys Acta</ISOAbbreviation></Journal><ArticleTitle>Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae.</ArticleTitle><Pagination><MedlinePgn>33-42</MedlinePgn></Pagination><Abstract><AbstractText>Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We report here that the expression of both genes is induced in response to various stress conditions including oxidative, osmotic, and heat stress and in response to stationary phase growth and growth on non-fermentable carbon sources. Furthermore, both genes are activated by the high-osmolarity glycerol pathway and negatively regulated by the Ras-protein kinase A pathway via stress-responsive STRE elements. GRX1 contains a single STRE element and is induced to significantly higher levels compared to GRX2 following heat and osmotic shock. GRX2 contains two STRE elements, and is rapidly induced in response to reactive oxygen species and upon entry into stationary phase growth. 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Beckhouse</name><name sortKey="Dawes, I W" sort="Dawes, I W" uniqKey="Dawes I" first="I W" last="Dawes">I W Dawes</name><name sortKey="Luikenhuis, S" sort="Luikenhuis, S" uniqKey="Luikenhuis S" first="S" last="Luikenhuis">S. Luikenhuis</name><name sortKey="Soderbergh, M" sort="Soderbergh, M" uniqKey="Soderbergh M" first="M" last="Soderbergh">M. Soderbergh</name></noCountry><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Grant, C M" sort="Grant, C M" uniqKey="Grant C" first="C M" last="Grant">C M Grant</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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